¼¶±ð: Ôº³¤
UID: 81347
¾«»ª: 0
·¢Ìû: 3397
ÍþÍû: 1 µã
»ý·Öת»»
ÓÞÓÞ±Ò: 11388 YYB
ÔÚÏß³äÖµ
¹±Ï×Öµ: 0 µã
ÔÚÏßʱ¼ä: 40(Сʱ)
×¢²áʱ¼ä: 2009-12-08
×îºóµÇ¼: 2021-07-16
Â¥Ö÷  ·¢±íÓÚ: 2015-05-11 08:24

 ¸´µ©´óѧҩѧԺ»ñµÃÈ«¹ú°ÙƪÓÅÐ㲩ʿÂÛÎĵÄÆÛÆ­ÐÐΪ

¸´µ©´óѧҩѧԺ»ñµÃÈ«¹ú°ÙƪÓÅÐ㲩ʿÂÛÎĵÄÆÛÆ­ÐÐΪ

×𾴵ķ½²©Ê¿,

¡¡¡¡×î½üÔÚ²éÕÒÏà¹ØÎÄÏ×ʱ·¢ÏÖ£º¸´µ©´óѧҩѧԺµ³Î¯Êé¼Ç½ΰԾѧÉúµÄÀîÁˆµÄ
È«¹ú°ÙƪÓÅÐ㲩ʿÂÛÎÄ£º¡®ÒÖÖÆp53ÓëMDM2½áºÏµÄ¿¹Ö×Áö¶àëÄÉè¼ÆÓë°ÐÏòµÝËÍ¡¯
´æÔÚÃ÷ÏÔµÄÖØ´óèÄå¡£½ÌÓý²¿Ñ§Î»ÓëÑо¿Éú½ÌÓý·¢Õ¹ÖÐÐÄ·¢²¼µÄ¹ØÓÚ2013ÄêÈ«¹ú
ÓÅÐ㲩ʿѧλÂÛÎÄÆÀÑ¡±¨ËͲÄÁϵÄ֪ͨÀïÃ÷È·Ö¸³ö£º¸÷Ïî³É¹û¾ùÓ¦Ó벩ʿѧλÂÛ
ÎÄÄÚÈÝÃÜÇÐÏà¹Ø£¬²¢ÄÜ·´Ó³Ñ§Î»ÂÛÎÄˮƽ£¬ÇÒΪ¹¥¶Á²©Ê¿Ñ§Î»Æڼ估»ñµÃ²©Ê¿Ñ§
λºóÒ»ÄêÄÚ»ñµÃ
£¨http://www.chinadegrees.cn/xwyyjsjyxx/zlpj/yblwpm/ybdtxx/277311.shtm
l£©£¬µ«ÊÇÀîÁˆ·¢±íµÄÂÛÎÄ£¨£Ð£õ£â£í£å£ä²éѯ£©¶¼ÊÇÒԣ̣õ¡¡£×£¨Â½Î°Ô¾ÔÚÂí
ÀïÀ¼´óѧµÄÇ×ÆÝ£©×÷Ϊ×îºóͨѶ×÷Õß·¢±íµÄ£¬¶ø½ΰԾ£¨£Ì£õ¡¡£×£Ù£©ÔòÊǵ¹Êý
µÚ¶þ»ò·ÇÖ÷ҪͨѶ×÷ÕßµÄÃûÒå·¢±í£¬×ö¿ÆѧµÄ¶¼Ã÷°×£¬ÈçÊÇ×Ô¼ºµÄѧÉúÔÚ×Ô¼ºµÄ
ʵÑéÊҵŤ×÷£¬Õ¦¿ÉÄÜÈ*************************À¹úµÄÇ×ÆÝ×öÁÐÔÚÖ÷ҪͨѶ×÷ÕßµÄλÖã¬ÄÇΨһµÄ½âÊÍ
ÊÇÄÇЩ¹¤×÷ÏÔÈ»ÊÇÔÚÃÀ¹úʹÓÃÊÒ×öµÄ£¬Ò²¾ÍÊÇÀîÁˆÎª¸´µ©´óѧȫÈÕÖÆѧÉúµ«¹¤×÷
¼¸ºõÈ«ÊÇÃÀ¹ú×öµÄ£¨ÊÂʵҲÊÇÀîÁˆ£³Ä격ʿÆÚ¼äÓУ²Äê¶àʱ¼äÊÇÔÚÃÀ¹ú£©£¬Èç¹û
Ö÷Òª¹¤×÷»ù±¾¶¼ÊǹúÍâʵÑéÊÒÍê³É£¨ÈçÏ·¢±íµÄÂÛÎÄÒÑ˵Ã÷ÁËÒ»ÇУ©£¬¶øÀ´Æ­È¡
¹úÄÚµÄÈ«¹ú°ÙƪÓŲ©Õâ²»ÊÇÆÛÆ­ÐÐΪÓÖÊÇɶ£¿¶øÇÒÀîÁˆ×÷ΪµÚÒ»×÷Õß·¢±íµÄ£µÆª
ÂÛÎÄ£¨Ò²¾ÍÊDzÎÆÀÓŲ©µÄ£µÆªÖУ´ÆªµÚÒ»µ¥Î»ÊÇÂíÀïÀ¼´óѧ¶ø·Ç¸´µ©£©£¬Î¨Ò»Ò»
ƪ£Ê£Â£ÃÊǸ´µ©µÚÒ»µ¥Î»£¨Èç¹û½öÒÔһƪ¹úÄڣʣ£úÎÒÔ»ñµÃÈ«¹úÓŲ©£¿£©£¬Ó¦
¸ÃÊǽΰԾÔÚÉ걨²ÄÁÏÀï°Ñ£´ÆªÂíÀïÀ¼ÎªµÚÒ»µ¥Î»µÄÂÛÎÄ¡¯´ò°ç¡¯³É¹úÄÚµÚÒ»µ¥
λÂÛÎÄ»ìÏýÆÀίµÄÊÓÏߣ¬¿öÇÒ½ΰԾֻÓб¾¿Æѧ룬Ëû×Ô¼º»¹ÔÚ¶ÁËùνµÄ²©Ê¿
£¨Òѱ»ÐÂÓïË¿ºÍÆäËûÍøÕ¾½Ò·¢´æÔÚѧλÔì¼ÙÏÓÒÉ£©£¬Ëû֮ǰÁíһѧÉúÕ¼²ýÓÑÒ²ÒÔ
ÀàËÆ·½·¨Æ­È¡£²£°£±£²Äê¶ÈµÄÈ«¹úÓŲ©£¬Á¬Ðø£²´ÎÆÛÆ­ÆÀίºÍ½ÌÓý²¿£¬Çë½ÌÓý²¿
ѧλÓëÑо¿Éú½ÌÓý·¢Õ¹ÖÐÐIJéʵ²¢¸ø¸ö˵·¨£¡

±¨È«¹úÓŲ©µÄÈçÏÂËùÁУ¨¾ùΪPubmed ²éѯ½á¹û£©£º

Àî ÁˆÂÛÎÄ£¨6ƪµÚÒ»×÷Õßoriginal articleÂÛÎÄÖнö£±Æª¸´µ©ÎªµÚÒ»×÷Õߣ©
Functional consequences of retro-inverso isomerization of a miniature protein inhibitor of the p53-MDM2 interaction.¡¡Li C1, Zhan C, Zhao L, Chen X, Lu WY, Lu W.¡¡Bioorg Med Chem. 2013 Jul 15;21(14):4045-50. doi: 10.1016/j.bmc.2013.04.039. Epub 2013 Apr 22.
Author information£¨×÷Õßµ¥Î»£©£º1College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China

D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplas.¡¡Liu M, Li C, Pazgier M, Li C, Mao Y, Lv Y, Gu B, Wei G, Yuan W, Zhan C, Lu WY, Lu W.¡¡Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14321-6. doi: 10.1073/pnas.1008930107. Epub 2010 Jul 26.
Author information£¨×÷Õßµ¥Î»£©£º1Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Limitations of peptide retro-inverso isomerization in molecular mimicry.¡¡Li C1, Pazgier M, Li J, Li C, Liu M, Zou G, Li Z, Chen J, Tarasov SG, Lu WY, Lu W.
J Biol Chem. 2010 Jun 18;285(25):19572-81. doi: 10.1074/jbc.M110.116814. Epub 2010 Apr 9.
Author information£¨×÷Õßµ¥Î»£©£º1School of Pharmacy, Fudan University, Shanghai 201203, China.

Systematic mutational ysis of peptide inhibition of the p53-MDM2/MDMX interactions.¡¡Li C 1, Pazgier M, Li C, Yuan W, Liu M, Wei G, Lu WY, Lu W.
J Mol Biol. 2010 Apr 30;398(2):200-13. doi: 10.1016/j.jmb.2010.03.005. Epub 2010 Mar 10.
Author information£¨×÷Õßµ¥Î»£©£º 1Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.

Apamin as a template for structure-based rational design of potent peptide activators of p53.¡¡Li C1, Pazgier M, Liu M, Lu WY, Lu W.¡¡Angew Chem Int Ed Engl. 2009;48(46):8712-5. doi: 10.1002/anie.200904550. No abstract available.
Author information£¨×÷Õßµ¥Î»£©£º 1Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.

Turning a scorpion toxin into an antitumor miniprotein.¡¡Li C, Liu M, Monbo J, Zou G, Li C 1, Yuan W, Zella D, Lu WY, Lu W.¡¡J Am Chem Soc. 2008 Oct 15;130(41):13546-8. doi: 10.1021/ja8042036. Epub 2008 Sep 18.
Author information£¨×÷Õßµ¥Î»£©£º 1Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.

Õ¼²ýÓÑÂÛÎÄ£¨£´ÆªµÚÒ»×÷Õßoriginal articleÂÛÎÄÖнö£±Æª¸´µ©ÎªµÚÒ»×÷Õߣ©
Total chemical synthesis of dengue 2 virus capsid protein via native chemical ligation: role of the conserved salt-bridge.¡¡Zhan C1, Zhao L, Chen X, Lu WY, Lu W.
Bioorg Med Chem. 2013 Jun 15;21(12):3443-9. doi: 10.1016/j.bmc.2013.04.035. Epub 2013 Apr 24.
Author information£¨×÷Õßµ¥Î»£©£º1Institute of Human Virology, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

An ultrahigh affinity d-peptide antagonist Of MDM2.
Zhan C1, Zhao L, Wei X, Wu X, Chen X, Yuan W, Lu WY, Pazgier M, Lu W.
J Med Chem. 2012 Jul 12;55(13):6237-41. doi: 10.1021/jm3005465. Epub 2012 Jun 22.
Author information£¨×÷Õßµ¥Î»£©£º1Institute of Human Virology, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Interrogation of MDM2 phosphorylation in p53 activation using native chemical ligation: the functional role of Ser17 phosphorylation in MDM2 reexamined.
Zhan C1, Varney K, Yuan W, Zhao L, Lu W.¡¡J Am Chem Soc. 2012 Apr 18;134(15):6855-64. doi: 10.1021/ja301255n. Epub 2012 Apr 4
Author information£¨×÷Õßµ¥Î»£©£º1Institute of Human Virology, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA

Micelle-based brain-targeted drug delivery enabled by a nicotine acetylcholine receptor ligand.¡¡Zhan C1, Li B, Hu L, Wei X, Feng L, Fu W, Lu W.¡¡Angew Chem Int Ed Engl. 2011 Jun 6;50(24):5482-5. doi: 10.1002/anie.201100875. Epub 2011 May 3.
Author information£¨×÷Õßµ¥Î»£©£º1School of Pharmacy & Key Laboratory of art Drug Delivery, Ministry of Education & PLA, Fudan University, Shanghai 201203, P.R. China.(SciFans.Net)
·ÖÏí:

ÓÞÓÞѧ԰ÊôÓÚ´¿Ñ§Êõ¡¢·Ç¾­ÓªÐÔרҵÍøÕ¾£¬ÎÞÈκÎÉÌÒµÐÔÖÊ£¬´ó¼Ò³öÓÚѧϰºÍ¿ÆÑÐÄ¿µÄ½øÐн»Á÷ÌÖÂÛ¡£

ÈçÓÐÉæÇÖ·¸Öø×÷ȨÈ˵İæȨµÈÐÅÏ¢£¬Ç뼰ʱÀ´ÐŸæÖª£¬ÎÒÃǽ«Á¢¿Ì´ÓÍøÕ¾ÉÏɾ³ý£¬²¢ÏòËùÓгְæȨÕßÖÂ×îÉîǸÒ⣬лл¡£