Increased Plaa Incretin Concentrations Identifies a Subset of Patientswith Persistent Congenital Hyperinsulini without KATPChannelGene Defects
Yanqin Shi, Hima B. Avatapalle, Mars S. Skae, Raja Padidela,Melanie Newbould, Lindsey Rigby
DOI:
http://dx.doi.org/10.1016/j.jpeds.2014.09.019 Abstract
Congenital hyperinsulini causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulini, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify these patients, and that elevated hormone levels may contribute to their pathophysiology.
