书籍名称 Classics in Total Synthesis 3
书籍作者 K. C. Nicolaou Jason S. Chen
出版社Weily
出版日期2011-4-12
页数: 770
Product Description
Adopting his didactically skillful approach, K.C. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods.
A wonderful tool for learning and teaching and a must-have for all future and present organic and biochemists.
From the Back Cover
Retaining his excellent, proven approach, world-famous chemist and passionate teacher K.C. Nicolaou and his student Jason S. Chen compile here the important strategies and tools employed to construct complex molecules. Through 42 syntheses of 25 challenging natural products they explain they key steps of the synthetic pathway, highlighting the major developments for easier understanding, and contrasting these to other synthetic methods. Similar to its predecessors and completing a trilogy, this textbook yzes the syntheses in a didactic manner, with several chapters including mini-reviews of key methodologies, and an emphasis on the history, mechani, scope, and generality of the reactions. In contrast to the first two volumes, this new one features full-color frontispieces .
A wonderful tool for learning and teaching, and a must-have for all current and future organic, medicinal and biological chemists.
From reviews of “Classics in Total Synthesis”, Volumes I and II:
“…a volume, (..) which any chemist with an interest in synthetic organic chemistry will wish to acquire.” –JACS
“…this superb book (..) will be an essential purchase for many organic chemists.” –Nature
“…Classics II is undoubtedly an excellent bargain that is highly recommended to everybody interested in advanced organic chemistry. …” –Angewandte Chemie 书籍目录：Chapter 1. Introduction: The Advancing Field of Total Synthesis.
1.1 Targets.
1.2 Strategies and Methods.
1.3 Classics in Total Synthesis III.
Chapter 2. Tetrodotoxin (Y. Kishi, J. Du Bois) (1972; 2003).
2.1 Introduction.
2.2 Kishi’s Retrosynthetic ysis and Strategy.
2.3 Kishi’s Totla Synthesis.
2.4 Du Bois’ Retrosynthetic Anaysis and Strategy.
2.5 Du Bois’ Total Synthesis.
2.6 Conclusion.
Chapter 3. Discodermolide (Novartis: S. J. Mickel, I. Paterson, A. B. ith, III) (2004).
3.1 Introduction.
3.2 Retrosynthetic ysis and Strategy.
3.3 Total synthesis.
3.4 Conclusion.
Chapter 4. Azaspiracid – I (K. C. Nicolaou, D. A. Evans) (2004, 2006, 2007).
4.1 Introduction.
4.2 Nicolaou’s Retrosynthetic ysis and Stratrgy.
4.3 Nicolaou’s Total Synthesis.
4.4 Evans’ Retrosynthetic ysis and Strategy.
4.5 Evans’ Total Synthesis.
4.6 Conclusion.
Chapter 5. Thiostrepton (K. C. Nicolaou) (2004).
5.1 Introduction.
5.2 Retrosynthetic ysis and Strategy.
5.3 Total Synthesis.
5.4 Conclusion.
Chapter 6. Pentacycloanammoxic Acid Methyl Ester (E. J. Corey (2004, 2006).
6.1 Introduction.
6.2 First-Generation Retrosynthetic ysis and Strategy.
6.3 First-Generation Total Synthesis.
6.4 Second-Generation Retrosynthetic ysis and Strategy.
6.5 Second-Generation Total Synthesis.
6.6 Conclusion.
Chapter 7. Littoralisone, Oseltamivir (Tamiflu®, and Hirsutellone B (D. W. C. MacMillan, Y. Hayashi, K. C. Nicolaou ) (2005, 2009, 2009).
7.1 Introduction.
7.2 Introduction to Littoralisone.
7.3 Total Synthesis of Littoralisone.
7.4 Introduction to Oseltamivir (Tamiflu®.
7.5 Total Synthesis of Oseltamivir (Tamiflu®.
7.6 Introduction to Hirsutellone B.
7.7 Total Synthesis of Hirsutellone B.
7.8 Conclusion.
Chapter 8. Rubicordifolin and Rubiocolin B (D. Trauner) (2005, 2008).
8.1 Introduction.
8.2 Retrosynthetic ysis of Rubicordifolin.
8.3 Total Synthesis of Rubicordifolin.
8.4 Retrosynthetic ysis of Rubioncolin B.
8.5 Total Synthesis of Rubioncolin B.
8.6 Conclusion.
Chapter 9. Cyanthiwigins U and F (A. J. Phillips, B. M. Stoltz) (2005, 2008).
9.1 Introduction.
9.2 Phillips’ Retrosynthesis ysis and Strategy.
9.3 Phillips Total Synthesis.
9.4 Stoltz’ Retrosynthetic ysis and Strategy.
9.5 Stoltz’ Total Synthesis.
9.6 Conclusion.
Chapter 10. Stephacidin B (A. G. Myers, P. S. Baran, R. M. Williams) (2005, 2005, 2007).
10.1 Introduction.
10.2 Myers’ Retrosynthetic ysis and Strategy.
10.3 Myers’ Total Synthesis.
10.4 Baran’s Retrosynthetic ysis and Strategy.
10.5 Baran’s Total Synthesis.
10.6 Williams’ Retrosynthetic ysis and Strategy.
10.7 Williams’ Total Synthesis.
10.8 Conclusion.
Chapter 11. Abyssomicin C and atrop-Abyssomicin C (E. J. Sorensen, K. C. Nicolaou) (2005, 2006).
11.1 Introduction.
11.2 Sorensen’s Retrosynthetic ysis and Strategy.
11.3 Sorensen’s Total Synthesis of Abyssomicin C.
11.4 Nicolaou’s Retrosynthetic ysis and Strategy.
11.5 Nicolaou’s Total Synthesis of Abyssomicin C and atrop-Abyssomicin C.
11.6 Conclusion.
Chapter 12. Tetracycline (A. G. Myers). (2005, 2007).
12.1 Introduction.
12.2 Retrosynthetic ysis and Strategy.
12.3 Total Synthesis.
12.4 Conclusion.
Chapter 13. Bisanthraquinone Natural Products (K.Nicolaou) (2005, 2009).
13.1 Introduction.
13.2 Retrosynthetic ysis and Strategy Toward 2,2’ –epi-Cytoskyrin A, Rugulosin, and Rugulin, and Rugulin.
13.3 Total Synthesis of 2,2’ –epi-Cytoskyrin A, Rugulosin, and Rugulin.
13.4 Retrosynthetic ysis and Strategy Toward Antibiotic BE-43472B.
13.5 Total Synthesis of Antibiotic BE-43472B.
13.6 Conclusion.
Chapter 14. Garsubellin A (M. Shibasaki, M. Kanai, S. J. Danishefsky) (2205, 2006).
14.1 Introduction.
14.2 Shibasaki and Kanai’s Retrosynthetic ysis and Strategy.
14.3 Shibasaki and Kanai’s Total Synthesis.
14.4 Danishefsky’s Retrosynthetic ysis and Strategy.
14.5 Danishefsky’s Total Synthesis.
14.6 Conclusion.
Chapter 15. Welwitindolinone A (P. S. Baran, J. L. Wood) (2005, 2006).
15.1 Introduction.
15.2 Baran’s Retrosynthetic ysis and Strategy.
15.3 Baran’s Total Synthesis.
15.4 Wood’s Retrosynthetic ysis and Strategy.
15.5 Wood’s Total Synthesis.
15.6 Conclusion.
Chapter 16. Iejimalide B (A. Fürstner) (2006, 2007).
16.1 Introduction.
16.2 Retrosynthetic ysis and Strategy.
16.3 Total Synthesis.
16.4 Conclusion.
Chapter 17. Kedarcidin Chromophore and Maduropeptin Chromophore (A. G. Myers, M. Hirama, M. Inoue, I. Sato) (2007, 2009).
17.1 Introduction.
17.2 Retrosynthetic ysis and Strategy for Kedarcidin Chromophore.
17.3 Total Synthesis of Kedarcidin Chromophore.
17.4 Retrosynthetic ysis and Strategy for Maduropeptin Chromophore.
17.5 Total Synthesis of Maduropeptin Chromophore.
17.6 Conclusion.
Chapter 18. Biyouranagin A (K. C. Nicolaou) (2007).
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18.1 Introduction.
18.2 Retrosynthetic ysis and Strategy.
18.3 Total Synthesis.
18.4 Conclusion.
Chapter 19. Azadirachtin (S. V. Ley) (2007, 2009).
19.1 Introduction.
19.2 Retrosynthetic ysis and Strategy.
19.3 Synthesis.
19.4 Conclusion.
Chapter 20. Resveratro-Derived Natural Products (S. A. Snyder, K. C. Nicolaou, D. Y.-K. Chen) (2007, 2009, 2010).
20.1 Introduction.
20.2 Snyder’s Retrosynthetic ysis and Strategy for a Collection of Resveratrol-Derived Natural Products.
20.3 Snyder’s Total Synthesis of a Collection of Resveratrol-Derived Natural Products.
20.4 Nicolaou and Chen’s Retrosynthetic ysis and Strategy for Hopeahainol A and Hopeanol.
20.5 Nicolaou and Chen’s Total Synthesis of Hopeahianol A and Hopeanol.
20.6 Conclusion.
Chapter 21. Chlorosulfolipid Cytotoxin (E. M. Carreira) (2009).
21.1 Introduction.
21.2 Retrosynthetic ysis and Strategy.
21.3 Total Synthesis.
21.4 Conclusion.
Chapter 22. Sporolide B (K. C. Nicolaou) (2009).
22.1 Inroduction.
22.2 Retrosynthetic ysis and Strategy.
22.3 Total Synthesis.
22.4 Conclusion.
Chapter 23. 11, 11’ –Dideoxyverticillin A and Chaetocin (M. Movassaghi, M. Sodeoka) (2009, 2010).
23.1 Introduction.
23.2 Retrosynthetic ysis and Strategy for 11, 11’ –Dideoxyverticillin A.
23.3 Total Synthesis of 11, 11’ –Dideoxyverticillin A.
23.4 Retrosynthetic ysis and Strategy for Chaetocin.
23.5 Total Synthesis of Chaetocin.
23.6 Conclusion.
Chapter 24. Vannusal B (K. C. Nicolaou) (2009).
24.1 Introduction.
24.2 Retrosynthetic ysis and Strategy.
24.3 Total Synthesis.
24.4 Conclusion.
Chapter 25. Haplophytine (T. Fukuyama, H. Tokuyama, K. C. Nicolaou, D.Y. –K. Chen) (2009, 2009).
25.1 Introduction.
25.2 Fukuyama and Tokuyama’s Retrosynthetic ysis and Strategy.
25.3 Fukuyama and Tokuyama’s Total Synthetis.
25.4 Nicolaou and Chen’s Retrosynthetic ysis and Strategy.
25.5 Nicolaou and Chen’s Total Synthesis.
25.6 Conclusion.
Chapter 26. Palau’amine (P. S. Baran) (2010).
26.1 Introduction.
26.2 Retrosynthetic ysis and Strategy.
26.3 Total Synthesis.
26.4 Conclusion.
Image / Photo Credits.
Author Index.
