作者 Javier Magano* and Joshua R. Dunetz*
Chemical Research and Development, Pharmaceutical Sciences, Pfizer
ABSTRACT: Herein we present a review on methods for carbonyl reductions on large scale ( ≥ 100 mmol) applied to the synthesis of drug candidates in the pharmaceutical industry. We discuss the most common and reliable methods for the reduction of aldehydes, ketones, carboxylic acids, esters, amides, imides, and acid chlorides. epresentative examples illustrate detailed reaction and workup conditions and highlight the advantages and limitations of each reducing agent with special emphasis on afety, cost, and amenability to scale-up.
本部分内容设定了隐藏,需要回复后才能看到
