Mass Spectrometry in Drug Discovery
Mass Spectrometry in Drug Discovery by David T. Rossi (Editor), Michael Sinz (Editor)
Publisher: CRC Press | 7 Nov 2001 | IN: 0824706072 | Pages: 432 | PDF | 10.1 MB
Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and ysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioysis automation, and computing, and demonstrates the use of mass spectrometry in the assesent of disease states, drug targets, and potential drug agents.
Table of Contents
Introduction: the demand for drug discovery today; the impact of atmospheric pressure ionisation. Part 1 Instrumentation: a mass spectrometry primer. Part 2 Experimental strategies: ion chemistry and fragmentation; the LC/MS experiment; sample preparation and handling for LC/MS in drug discovery. Part 3 Applications: mass spectrometry in combinatorial chemistry; drug hydrophobicity and transport; the mass spectrometer in drug metaboli; mass spectrometry-assisted applications of stable-labeled compounds in pharmacokinetic and drug metaboli studies; cassette dosing in drug discovery; applications of microdialysis/mass spectrometry to drug discovery; future directions for mass spectrometry in drug discovery.
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