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楼主  发表于: 2011-03-21 20:38
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 Biologist Postdoc Fellow

Job Title: Biologist Postdoc Fellow
Profession: Biotechnology/Pharmaceuticals -> Scientific Research Professionals
Job Title:Biologist Postdoc Fellow
Req Number:25105
Division:Physical BiosciencesDepartment:
------ Be part of something great!The Physical Biosciences Divison has an opportunity for a Biologist Postdoctoral Fellow to support a research collaboration. The candidate will be involved in two sub-projects: (1) studying cellular transport systems (pumps, transporters) that increase export of toxic target metabolites and play a role in alleviating toxicity in microbial production host; and (2) survey gene expression data from microbial stress response studies for regulatory elements that can be used to develop regulatable promoters in microbes. The primary role of this postdoctoral position will be to create deletion and expression strains in both gram positive bacterial hosts and survey for improved stress tolerance and metabolite production activity.As a Postdoc, you will:
------ * Obtain from strain banks, or create strains for series of transporters and efflux pumps, relevant to target compounds and express in corresponding microbial hosts (e.g. Bacillus spp, Streptococcus spp). Test resultant strains for effect on fuel production or alleviation of growth stress.
------ * Utilize existing library of transport pump strains to screen efficacy against metabolic targets for microbial production.
------ * Develop methods to assay for increase in specific production of metabolite.
------ * Survey microarray and other cell wide data available in the literature or acquired at JBEI for cellular response to toxic effects of target compound production of metabolic engineering stress. Use this data to predict regulatable transcription systems that can be used for creating regulatable promoters in metabolic engineering.
------ * Prepare manuscripts for publication and assist with the development of funding proposals and patents.
------ * Participate in group meetings, seminars and training.
------ * Maintain an accurate and detailed scientific logbook of all experiments performed. Ensure that others could duplicate results.
------ * ? Responsible for periodic reports to the Director of the project and Project Coordinator, participation in group meetings, training research assistants and assisting others in the lab who require giudance with gene manipulation studies.

Key Success Factors:
------ * Recent PH.D in Microbiology, Chemistry, Biochemistry, Molecular Biology or related areas.
------ * Expert knowledge in handling model microbes such as B. Subtilis, Streptococcus spp including growth, culturing, transformation, gene manipulation, creation of expression systems and protein purification.
------ * Experience with working with microbial transport systems, efflux and transport pumps and microbial regulatory mechanis and stress response.
------ * Ability to work with guidance of a director or principal investigator and collaborators and well as to conduct experiments independently, maintain appropriate records and manage data.
------ * Strong verbal and written communication skills with ability to write grant proposals and establish independent funding.
------ * Experience with scientific journal writing submissions and ability to write above average reviews and articles for submission.
------ * Experience strategies such as directed evolution or protein structure function ysis.
---------- Notes----------
This is a full time, one-year term appointment with the possibility of renewal contingent upon continued funding and satisfactory performance.
---------- Berkeley Lab is an affirmative action/equal opportunity employer committed to the development of a diverse workforce.
Desired Attributes Profession:
Biotechnology/Pharmaceuticals -> Scientific Research Professionals
Research/Training: Academic/post doctoral research
Research Specialization: Microbial systems
Research/Training: 0-2 Years
Company Name: Lawrence Berkeley National Laboratory
Apply Online:   Employer's Website
Location: Berkeley
Available:Immediately.
Posted:3/19/11
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