Enzymatic Reaction Mechanisms 1 Edition

Enzymatic Reaction Mechanis
# Hardcover: 848 pages
# Publisher: Oxford University Press, USA; 1 edition (January 27, 2007)
# Language: English
# IN-10: 0195122585
# IN-13: 978-0195122589

Product Description
Books dealing with the mechanis of enzymatic reactions were written a generation ago. They included volumes entitled Bioorganic Mechanis, I and II by T.C. Bruice and S.J. Benkovic, published in 1965, the volume entitled Catalysis in Chemistry and Enzymology by W.P. Jencks in 1969, and the volume entitled Enzymatic Reaction Mechanis by C.T. Walsh in 1979. The Walsh book was based on the course taught by W.P. Jencks and R.H. Abeles at Brandeis University in the 1960's and 1970's. By the late 1970's, much more could be included about the structures of enzymes and the kinetics and mechanis of enzymatic reactions themselves, and less emphasis was placed on chemical models. Walshs book was widely used in courses on enzymatic mechanis for many years. Much has happened in the field of mechanistic enzymology in the past 15 to 20 years. Walshs book is both out-of-date and out-of-focus in todays world of enzymatic mechanis. There is no longer a single volume or a all collection of volumes to which students can be directed to obtain a clear understanding of the state of knowledge regarding the chemicals mechanis by which enzymes catalyze biological reactions. There is no single volume to which medicinal chemists and biotechnologists can refer on the subject of enzymatic mechanis. Practitioners in the field have recognized a need for a new book on enzymatic mechanis for more than ten years, and several, including Walsh, have considered undertaking to modernize Walshs book. However, these good intentions have been abandoned for one reason or another. The great size of the knowledge base in mechanistic enzymology has been a deterrent. It seems too large a subject for a single author, and it is difficult for several authors to coordinate their work to mutual satisfaction. This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text.

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