自动信息发布工具，可以访问君笨笨贴吧看看哟组学 ? 进展 市场 人物 公司 会议 下一代测序 首页 ? 组学 ? TheraAdvinUrol：年轻女孩患泌尿道感染的潜在风险因子 Thera Adv in Urol：年轻女孩患泌尿道感染的潜在风险因子 来源：生物谷 2014-08-24 13:19 2014年8月24日 讯 /生物谷BIOON/ --近日，刊登在国际杂志Therapeutic Advances in Urology上的一篇研究论文中，来自美国威克森林浸信医学中心（Wake Forest Baptist Medical Center）的研究人员通过研究表示，外生殖器伴有剧烈难忍皮疹的年轻女孩儿或许引发泌尿道感染（UTIs）的风险价偏高。研究者Steve J. Hodges教授表示，外阴炎是一种影响各个年龄段女性健康的常见病症，我们发现，相比没有外阴炎的女孩儿来讲，外阴炎女孩儿患泌尿道感染的可能性是前者的8倍以上。这项研究中，研究者对有泌尿道感染症状的101名女孩（2-8岁）的上厕所习惯进行调查研究，同时研究人员对参与者的尿液以及外阴拭子进行实验室分析，结果发现，超过57%的可疑泌尿道感染的女孩儿均有外阴炎的症状，而对尿液检测发现，在101名参与者中有35%的个体患有泌尿道感染而且有86%的个体患有外阴炎。在10个有外阴炎的个体中就有8人机体中存在和泌尿道感染的相关微生物，比如大肠杆菌。研究者假设，和外阴炎相关的炎症会引发泌尿道感染；炎症会扰乱外阴区域正常细菌的生长，使得引发泌尿道感染的细菌更加具有竞争力而生存下去，从而引发泌尿道感染。研究者建议，住院医生需要对女孩儿是否患有外阴炎进行检查，如果发现有该病症，需要连同家长一起对这些患者进行治疗，预防病症再次发生。泡沫浴、游泳池水、尿液和粪便的暴露或许为个体引发外阴炎甚至是泌尿系统感染提供一种促炎性环境，而本文的研究也证实了某些游泳池水或洗浴水或许会增加引发炎症的细菌生存繁衍的能力，进而引发个体患病。（yuyu学院）doi:10.1177/1756287214542097PMC:PMID:Altered perineal biome is associated with vulvovaginitis and urinary tract infection in preadolescent girlsI. Gorbachinsky, R. Sherertz, G. Russell, L. S. Krane, S. J. Hodges.Background: Vulvovaginitis has a known association with urinary tract infections (UTIs) in girls. We hypothesize that vulvovaginitis is a major contributor to UTIs in prepubertal girls by increasing periurethral colonization with uropathogens. Methods: Periurethral swabs and urine specimens were obtained from a total of 101 girls (58 with vulvovaginitis and 43 without vulvovaginitis). Specimens were cultured for bacterial growth. The dominant organi in the periurethral swabs and urine cultures was recorded and antibiotic sensitivity profiles were compared. Results: Periurethral swabs from children with vulvovaginitis were associated with a statistically significant increase in uropathogenic bacteria (79% Enterococcus species or Escherichia coli) as the dominant culture compared with swabs from girls without vaginitis (18%) (p?<?0.05). In children with vulvovaginitis, 52% of the urine cultures were positive for UTIs, and the dominant organi in the urine cultures matched the species and antibiotic sensitivity profile of the corresponding periurethral swab. Only 11% of the urine cultures from girls without vulvovaginitis were positive for UTIs. Conclusions: Vulvovaginitis may cause UTIs by altering the perineal biome such that there is increased colonization of uropathogens.
