2014年8月14日 Nature
The COP9 signalosome (CSN) is a large protein complex that functions in the ubiquitin–proteasome intracellular protein degradation pathway. First identified 20 years ago in developing
Arabidopsis seedlings, it is now thought to be part of the regulatory machinery in all animals, plants and fungi. Here,
Nicolas Thomä and co-workers present the crystal structure of the entire eight-subunit human COP9 signalosome at 3.8 Å resolution, providing insights into its molecular architecture and mechani of action. The structure reveals how the complex achieves such exquisite specificity for its substrates. Cover: Thomas Splettstoesser.
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