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楼主  发表于: 2011-01-17 17:10

 英翻中(Crystal storing histiocytoma)

一个疾病的名称,真的翻译不出来, 请高手指教………………
以下是疾病介绍:
Crystal Storing Histiocytocis
In this rare condition there is massive accumulation of
crystallized immunoglobulins in nodular collections of
histiocytes77,78 (Fig. 4E). It is usually associated with
plaa cell dyscrasias, monoclonal gammopathies, and
other lymphoid neoplas. In these situations it may
manifest as a systemic process (crystal storing histiocytosis),
although it may also present as a mass lesion in the lung or
other organs including the kidney, liver, and bone marrow
among others. An association with collagen vascular
disease (rheumatoid arthritis) has also been described.
Immunohistochemically, the histiocytes have been shown
to be positive for CD68, CD43, and lysosome, and weakly
positive for k and l light chains, and IgM. S-100, B-cell and
T-cell markers (CD20 and CD3), and cytokeratin stains are
negative. In the context of an underlying lymphoproliferative
disorder, the prognosis is thought to be poor, although in
cases with an isolated pulmonary crystal storing histiocytoma,
it may behave like a reactive entity with good prognosis.77
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1楼  发表于: 2011-01-20 23:15
crystal storing histiocytosis是一种罕见的浆细胞性骨髓瘤(多发性骨髓瘤),表现为浆细胞浆内(溶酶体内)沉积大量免疫球蛋白结晶(免疫球蛋白 kappa 轻链)。详见http://www.ncbi.nlm.nih.gov/pubmed/10667422http://so.med.wanfangdata.com.cn/ViewHTML/PeriodicalPaper_JJ0215783025.aspxhttp://www.myyao.com/bz/531/5326_discheck.html在透射电子显微镜下,瘤细胞的显著特征是内质网的增多和扩大,高尔基(Golgi)体极为发达。扩大的粗面内质网内含无定形物、椭圆形小体,这些物质与血清中M蛋白有关。发达的高尔基体内含致密小体和空泡。线粒体也增多、增大嵴丰富。常可见到胞质内有空泡拉塞尔小体、结晶体、包涵体。胞核大而圆,常偏于一侧,核染色质较粗,核仁大而多形化,有时可见核内包涵体胞核与胞质发育成熟程度不成比例是瘤细胞在透射电子显微镜下的重要特征。
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