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    ¡¡¡¡ÎÒÔøÉóÔÄÀ´×ÔClin ImmunolµÄÒ»·Ý¸å¼þ£¬ÊǹØÓÚ×ÔÉí¿¹ÌåÑÇÀàÓëÆ÷¹ÙÌØÒìÐÔËðº¦Ö®¼ä¹ØϵµÄÂÛÎÄ£¬×÷ÕßÊÇÃÀ¹úijʵÑéÊҵģ¬´ÓÃû×Ö¿´ÀÏ°åÓ¦¸ÃÊÇÃÀ¹úÈË¡£ËûÒýÓÃÁËÎÒµÄһƪÎÄÕ£¬µ«Êǹ۵ãÓеãÇú½â¡£ÎÒÉÆÒâµÄ¸øËûÖ¸³öÀ´£¬»¹¸æËßÎÒµÄÀÏ°åµÄÁíһƪÎÄÕÂÒ²Ó¦¸ÃÒý½øÈ¥¡£¸å¼þÐÞ»áºó£¬·¢ÏÖËûÕÕ×öÁË£¡ÎÒÔò±íʾͬÒâ·¢±í¡£µ±È»£¬×î³õÒòΪËûÒýÓÃÁËÎÒµÄÎÄÕ£¬Îҿ϶¨ÊDz»»áËæÒâǹ±ÐËûµÄ¸å¼þµÄ£¬¹þ¹þ£¡ÎÒµ±Ê±ÔÚ³õÉóÒâ¼ûÖÐдµÀ£ºIn this manuscript, Jardan et al demonstrated that  antibodies contribute to inducing (ÂÔ) phenotypic changes in  cells both in vivo and in vitro. This result provides us an important insight in the pathogenesis of lupus nephritis induced by . I think authors well prepared this paper and did steady work. Interpretation for their results seems appropriate. (¶à¶àÃÀÑÔ) I have the following minor comments(°µÊ¾ÎÄÕÂÓ¦±»½ÓÊÜ)

    ¡¡¡¡2. ÈçºÎ¸ø×Ô¼ºµÄ¸å¼þ¶¨Î»ÓÚºÎÖÖÔÓÖ¾£ºÃ¿¸ö×÷Õ߶¼ÆÚÍû×Ô¼ºµÄÎÄÕÂÄÜ·¢µ½IF¾¡¿ÉÄܸߵÄÔÓÖ¾¡£¹úÍâµÄÀÏ°åͨ³£¶Ô×Ô¼ºµÄÁìÓò·Ç³£Çå³þ£¬ÍùÍùÔÚʵÑéÉè¼Æ½×¶Î¾ÍÖªµÀÁËͶ¸å·½Ïò£¬½á¹û³öÀ´ºó¾Í¿ÉÈ·¶¨·¢±íÓÚºÎÖÖÔÓÖ¾¡£¹úÄÚʵÑéÊÒ³£³£Ã»ÓÐÕâÖÖˮƽ£¬ÄÇÔõô°ì£¿Îҵľ­ÑéÊÇ£º°ÑÎÄÕ´óÖÂдÍêºó£¬¿´¿´ÄãÖ÷ÒªÒýÓÃÁËÄÄЩÔÓÖ¾µÄÎÄÏ×£¬ÕâЩ×÷ÕßÖ÷ÒªÔÚÄÄЩÔÓÖ¾ÉÏ·¢±íÂÛÎÄ£¿È»ºó¾Í¿ÉÈ·¶¨ÄâͶ¸åµÄÔÓÖ¾£¬´óÖÂ**²»ÀëÊ®¡£

    ¡¡¡¡2009ÄêÎÒÊÕµ½À´×ÔExp DermatolµÄÉó¸åÐÅ£¬ÊǹØÓÚmoesin familyµ°°×µÄһƪÂÛÎÄ¡£×÷ÕßÔòÊÇUniversity of Cincinnati Medical CenterʵÑéÊҵġ£ÃÀ¹úÈËдµÄÂÛÎÄÓïÑԿ϶¨Ã»ÎÊÌ⣬ͼƬҲºÜƯÁÁ¡£µ«ÎÒÔĶÁºó£¬¸Ð¾õûʲôÐÂÒ⣬ʵÑéÉè¼Æ¹ýÓÚ¼òµ¥£¬½ö½öÓ*************************âÒß×黯ºÍwestern blotÖ¤Ã÷¹Ûµã£¬ÌÖÂÛ²¿·Ö²»ÉîÈ룬ÒýÓõÄÎÄÏ×¼¯ÖÐÓÚһЩ²»ÉõÖªÃûµÄÔÓÖ¾¡£ÎÒÓÚÊǸøµÄÆÀÓï²»ÊǺܺã¬ÈçÏ£º

    ¡¡¡¡1. The scoring criteria is extremely important for the histological evaluation of BCC and trichoblastoma. But it was not mentioned in this manuscript if such a criteria had been used before. An authoritative reference may be convincing.

    ¡¡¡¡2. Results comments and figure legends are not clear enough to be able to follow the figures without referring constantly to the sections. Authors should explain if any significant difference between BCC and trichoblastoma in Fig.1.

    ¡¡¡¡3. On page 4 line 48-50, authors wrote " The difference between the staining patterns was statistically significant with a p-value <0.05." Its confusing and misleading. How can they compare the staining patterns statistically? Fig.3 doesnt reflect this conclusion. Please clarify.

    ¡¡¡¡4. On page 4 line 25-27, the "normal skin" means what? Its not rigorous to consider surrounding tissue as normal skin when evaluating BCC or trichoblastoma. Its better to stain normal skin from other site and then do this comparison.

    ¡¡¡¡5. Some very important opinions appeared in the discussion section without related citation. For example, "(ÂÔ) normally exists in an activated state at the cell membrane and an inactive state in the cytopla. It appears that in certain neoplas this relationship may be reversed with increased cytoplaic activation and decreased membrane activation."

    ¡¡¡¡6. Some abbreviations (e.g. BCC, SCC) need to be explained at first appearance in the text. Some references could be updated, and all references should be given in a consistent style.

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