¼¶±ð: Ôº³¤
UID: 81904
¾«»ª: 0
·¢Ìû: 1972
ÍþÍû: 15 µã
»ý·Öת»»
ÓÞÓÞ±Ò: 311 YYB
ÔÚÏß³äÖµ
¹±Ï×Öµ: 0 µã
ÔÚÏßʱ¼ä: 30(Сʱ)
×¢²áʱ¼ä: 2009-12-15
×îºóµÇ¼: 2022-08-22
Â¥Ö÷  ·¢±íÓÚ: 2018-12-15 11:27

 ¿Æѧ¼Ò½Òʾ¶¯ÎïÌåÖá³ÉÒò

ÓÞÓÞѧ԰www.SciFans.netÎÂÜ°Ìáʾ£º
11ÔÂ23ÈÕ£¬Ç廪´óѧÃÏ°²Ã÷ԺʿÑо¿×éÓëÌÕÇ컪½ÌÊÚÑо¿×éºÏ×÷£¬ÔÚ¹ú¼Ê¶¥¼¶ÆÚ¿¯¡¶¿Æѧ¡·£¨Science£©ÔÚÏß·¢±íÁËÌâΪ¡****************¸Ô´Òò×ÓHuluwaͨ¹ý-catenin¾ö¶¨¼¹×µ¶¯ÎïÅßÌ¥ÌåÖá¡·£¨Maternal Huluwa dictates the embryonic body axis through -catenin in vertebrates£©µÄÑо¿³¤ÎÄ£¬Ê״ᨵÀÁËĸԴ»ùÒòhuluwaÔÚ¼¹×µ¶¯ÎïÅßÌ¥±³²¿×éÖ¯ÖÐÐļ°ÌåÖáÐγÉÖеľö¶¨ÐÔ×÷Ó㬸ÃÑо¿³É¹ûÊÇÅßÌ¥·¢ÓýÉúÎïѧÁìÓòµÄÖØ´ó½øÕ¹¡£
    
        
    
        È˺Ͷ¯ÎïµÄÇûÌåÓÐÁ½ÌõÖ÷ÒªÖáÏߣºÍ·Î²ºÍ±³¸¹ÖáÏߣ¬¸÷ÖÖ×éÖ¯Æ÷¹ÙÑØÆäÒÀÐòÅÅÁС£ÔÚ¼¹×µ¶¯ÎïÅßÌ¥·¢ÓýÔçÆÚ£¬Ö÷ÒªÒÀÀµÓÚ±»³ÆΪ×éÖ¯ÖÐÐÄ£¨Organizer£©µÄÇøÓòµÄ×÷Ó㬽«ÕâÁ½ÌõÖáÏßÖð½¥½¨Á¢¡£ÔçÔÚÉÏÊÀ¼Í¶þÊ®Äê´ú£¬µÂ¹úÅß̥ѧ¼ÒººË¹.˹ÅåÂü£¨Hans Spemann£©ºÍÏ£¶ûµÂ.Âü¸ê¶ûµÂ£¨Hilde Mangold£©ÔÚòîó¢µÄÑо¿Öз¢ÏÖÁËÅßÌ¥×éÖ¯ÖÐÐÄ£¬Ë¹ÅåÂüÒ²Òò´Ë¶ø»ñµÃÁË1935Äêŵ±´¶ûÉúÀíҽѧ½±¡£
    
        
    
        ´ËºóµÄ´óÁ¿Ñо¿¹¤×÷±íÃ÷£¬ÅßÌ¥×éÖ¯ÖÐÐÄÊÇÒ»¸öÐźÅÖÐÐÄ£¬Í¨¹ýµ÷¿Øϸ°ûÃüÔ˺Íϸ°ûÔ˶¯£¬µ¼ÖÂÅßÌ¥ÐÎ̬µÄ¿ìËٸı䣬ÅßÌ¥Ðγɸ÷¸öÅ߲㲢»ñµÃÀàËƳÉÄêºóµÄÇûÌåÂÖÀª£»×éÖ¯ÖÐÐÄÐγɵĹؼüÊÇʹϸ°ûÖÊÖеÄ-cateninµ°°×½øÈëϸ°ûºË£¬¼¤»îÆäËü°Ð»ùÒòµÄ±í´ï¡£È»¶ø£¬ÊÇʲôÒò×ÓÌØÒìÐÔÓÕµ¼×éÖ¯ÖÐÐÄÇ°Ìåϸ°ûÖеÄ-cateninµ°°×½øÈëϸ°ûºË£¬Ñо¿½çһֱûÓÐÃ÷È·´ð°¸¡£
    
        
    
        ÃÏ°²Ã÷ԺʿÑо¿×é·¢ÏÖÁËÒ»ÖÖ°ßÂíÓãÍ»±äÌ壬´ÆÐÔÍ»±äÌåµÄÂÑ×ÓÊܾ«ºó£¬ËùÓеÄÅßÌ¥²»ÄÜÐγÉ×éÖ¯ÖÐÐÄÒÔ¼°Í·²¿ºÍÇû¸É£¬Ã»ÓÐÕý³£Í·Î²ºÍ±³¸¹ÖáÏ߽ṹ£¨Í¼1£©¡£Í¨¹ýϸÖµĻùÒò¶¨Î»Ñо¿£¬·¢ÏÖÍ»±ä±íÐͳöÏÖµÄÔ­ÒòÊÇÂÑ×ÓÖÐȱÉÙÁËÒ»¸öĸÌå»ùÒòµÄ²úÎï¡£Òò¸Ã»ùÒòÊÇÒ»¸ö´ÓδÓй¦Äܱ¨µ¼¡¢Ò²Ã»ÓỶ¨ÃûµÄ»ùÒò£¬ËûÃǽ«¸Ã»ùÒò¶¨ÃûΪhuluwa£¬¼´ÖÐÎĵĺù«ÍÞ£¬Ô´ÓÚÒ»²¿·ÖÍ»±äÌåÅßÌ¥µÄÐÎ×´ÀàËÆÓÚºù«£¨Í¼1£©¡£
    
        
    
        Ñо¿Õß½«ÌåÍâºÏ³ÉµÄhuluwaµÄmRNA×¢Éäµ½¶àϸ°ûÆÚÅßÌ¥µÄÒ»¸öϸ°ûÖУ¬¿ÉÒÔ¸ßЧµØÓÕµ¼³öÒ»¸ö¶îÍâµÄ×éÖ¯ÖÐÐÄ£¬¼ÌÖ®ÒÔÐγÉÒ»¸ö¶îÍâµÄÇûÌ壬¾ÍÏñË«°ûÌ¥Ò»Ñù£¬ËµÃ÷Æä¾ßÓÐÇ¿´óµÄ×éÖ¯ÖÐÐÄÓÕµ¼ÄÜÁ¦¡£ÌÕÇ컪½ÌÊÚÑо¿×é½Ó×ÅÖ¤Ã÷£¬½«×¦ÍÜÂÑ×ÓÖÐhuluwaµÄmRNAÌÞ³ýºó£¬Êܾ«ÂÑÒ²²»ÄÜ·¢ÓýÐγÉ×éÖ¯ÖÐÐÄ£¬Ö®ºó²»ÄÜÐγÉÍ·²¿ºÍÇû¸É£»×¢ÉäÍâÔ´huluwa mRNAÒ²¿ÉÒÔÓÕµ¼¶îÍâµÄÇû¸É£¬ËµÃ÷ÓãÀàºÍÁ½ÆÜÀàhuluwaµÄ¹¦ÄÜÊÇÏàͬµÄ¡£
    
        
    
        
    
        
    
        Í¼1. Huluwa(¼ò³ÆHwa)ÔÚ°ßÂíÓãÅßÌ¥ÖеÄ×÷ÓÃģʽ¡£ÔÚÒ°ÉúÐÍÊܾ«ÂÑÖУ¬hwa mRNA¶¨Î»ÔÚÓªÑø¼«£¬¶øÖáµ°°×£¨Axin£©ºÍ-cateninµ°°×¶¨Î»ÔÚ¶¯ÎK°ûÖÊÖС£ÔÚÄÒÅ߽׶Σ¬Hwaµ°°×¶¨Î»ÔÚδÀ´±³²¿Çøϸ°ûµÄÖÊĤÉÏ£¬´Ù½øÖáµ°°×½µ½â£¬°ûÖÊÖеÄ-cateninתÔ˵½Ï¸°ûºËÖУ¬´Ó¶øÔÚÔ­³¦ÅßÐγÉ×éÖ¯ÖÐÐÄ£¬×éÖ¯ÖÐÐĵÄÐźÅÍøÂçÔÙ¾ö¶¨±³¸¹ºÍÇ°ºóÖáÏßµÄϸ°ûÃüÔË·Ö»¯¼°Ï¸°ûµÄÔ˶¯·½Ïò£¬Òò¶øÕý³£·¢Óý²¢²úÉúÕý³£µÄÐÎ̬¡£ÔÚhwaĸԴͻ±äÌ壨Mhwa£©ÖУ¬ÒòȱʧÂÑÔ´hwa mRNA£¬ÄÒÅß±³²¿Ï¸°ûÖеÄAxin²»Êܽµ½â£¬´Ó¶øÒýÆð-catenin½µ½â¡¢×éÖ¯ÖÐÐIJ»ÄÜÐγɣ¬24СʱʱµÄÅß̥ΪûÓÐÍ·²¿ºÍÇû¸ÉµÄºù«ÐλòÑó´ÐÐΡ£O£¬×éÖ¯ÖÐÐÄ£»N£¬Éñ¾­ÍâÅ߲㣻EP£¬±íƤÍâÅ߲㣻ME£¬ÖÐÄÚÅ߲㡣
    
        
    
        ½øÒ»²½Ñо¿½á¹ûÏÔʾ£¬ÔçÆÚÅßÌ¥ÖÐHuluwaµ°°×¶¨Î»ÔÚδÀ´±³²¿ÇøÓòϸ°ûµÄÖÊĤÉÏ£¬ËüÕÐļÖáµ°°×£¨Axin£©ºóÕßÊÇÓë-catenin½áºÏ²¢µ¼ÖÂÆä½µ½âµÄ¹Ø¼üµ°°×¡£ÓëHuluwa½áºÏµÄÖáµ°°×½«±»½µ½â£¬´Ó¶ø±£»¤-catenin²»±»½µ½â¶ø¿ÉÒÔתÔ˵½Ï¸°ûºËÖз¢»Ó×÷Ó᣹ýÈ¥ÈÏΪÂÑ×ÓÀ´Ô´µÄWntÅäÌåºÍÊÜÌå½áºÏ²úÉúµÄÐźű£»¤ÁËÅß̥δÀ´±³²¿ÇøÓòµÄ-catenin£¬µ«¸ÃÑо¿·¢ÏÖWntÅäÌå/ÊÜÌåÔÚÔçÆÚÅßÌ¥ÖкܿÉÄܲ»·¢»ÓÕâÖÖ×÷Óã¬Huluwa¶Ô-cateninµÄ±£»¤×÷Óò»ÒÀÀµÓÚWntÅäÌå/ÊÜÌåÐźš£Òò´Ë£¬HuluwaÊÇ·¢ÓýÉúÎïѧ¼Ò³¤¾ÃÒÔÀ´¿à¿à×·Ñ°µÄÒ»¸öÅßÌ¥±³²¿¾ö¶¨Òò×Ó¡£
    
        
    
        ÃÏ°²Ã÷ԺʿºÍÌÕÇ컪½ÌÊÚΪ¸ÃÏîÑо¿µÄ¹²Í¬Í¨Ñ¶×÷Õߣ¬Ç廪´óѧÉúÃüѧԺ²©Ê¿ÉúêÌè´¡¢²©Ê¿ºó³Â¾²ºÍÖìѦ³½Îª¹²Í¬µÚÒ»×÷Õߣ»ÆäËû¹²Í¬×÷ÕßËï¼Îΰ¡¢ÎâСͯ¡¢Éòì¿Ãô¡¢ÕÅμӨҲ²ÎÓëÁ˲¿·ÖʵÑ鹤×÷¡£¸ÃÑо¿µÃµ½¹ú¼Ò×ÔÈ»¿Æѧ»ù½ðί¡¢Öйú²©Ê¿ºó¿Æѧ»ù½ðÒÔ¼°Ç廪´óѧ×ÔÖ÷¿ÆÑо­·Ñ×ÊÖú¡££¨À´Ô´£ºÇ廪ÐÂÎÅÍø£©
    
        
    
        Ïà¹ØÂÛÎÄÐÅÏ¢£ºDOI: 10.1126/science.aat1045
¼¶±ð: ¸±½ÌÊÚ
״̬: δǩµ½ - [1912Ìì/1912´Î]
UID: 48210
¾«»ª: 0
·¢Ìû: 3474
ÍþÍû: 30 µã
»ý·Öת»»
ÓÞÓÞ±Ò: 8066 YYB
ÔÚÏß³äÖµ
¹±Ï×Öµ: 0 µã
ÔÚÏßʱ¼ä: 3705(Сʱ)
×¢²áʱ¼ä: 2008-08-30
×îºóµÇ¼: 2023-02-08
1Â¥  ·¢±íÓÚ: 2018-12-22 10:17
ѧϰÏÂ
·ÖÏí:

ÓÞÓÞѧ԰ÊôÓÚ´¿Ñ§Êõ¡¢·Ç¾­ÓªÐÔרҵÍøÕ¾£¬ÎÞÈκÎÉÌÒµÐÔÖÊ£¬´ó¼Ò³öÓÚѧϰºÍ¿ÆÑÐÄ¿µÄ½øÐн»Á÷ÌÖÂÛ¡£

ÈçÓÐÉæÇÖ·¸Öø×÷ȨÈ˵İæȨµÈÐÅÏ¢£¬Ç뼰ʱÀ´ÐŸæÖª£¬ÎÒÃǽ«Á¢¿Ì´ÓÍøÕ¾ÉÏɾ³ý£¬²¢ÏòËùÓгְæȨÕßÖÂ×îÉîǸÒ⣬лл¡£