| 内科医生 |
2016-01-05 11:38 |
近日，根据8月28日在线发表在《Head 这个meta分析结果有力的证明了有关幽门螺旋杆菌感染与咽喉癌之间存在联系，特别是通过聚合酶链反应(PCR)和酶联免疫吸附试验(ELISA)进行确证后。作者写道。然而，通过分析发现幽门螺旋杆菌感染和鼻咽癌之间没有发现明显的关联迹象。此外，少量参与这项研究的项目在这个评估中引起了较大的置信区间。
doi:10.1002/hed.24214
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PMID:
Association between helicobacter pylori infection and carcinoma of the larynx or pharynx
Jian Zhou PhD, Duo Zhang PhD, Yue Yang MD, Liang Zhou PhD andLei Tao PhD*
Background Infection with Helicobacter pylori (H. pylori) plays a role in the development of gastric carcinoma. However, there is controversy as to whether H. pylori infection increases laryngeal or pharyngeal cancers. Methods We managed a systematic review of researches related to H. pylori infection in laryngeal or pharyngeal carcinomas, distributed up to December 2014. Odds ratios (ORs) and 95% confidence intervals (CIs) were assessed by random effects models or according to heterogeneity I2. Results Eleven studies were involved in the meta-ysis. Overall, H. pylori infection was significantly higher in the study group compared with the normal control group (OR = 2.87; 95% CI = 1.71–4.84; I2 = 67.1; p <.0001, random effects ysis). The ORs for laryngeal carcinoma were 3.28 (95% CI = 1.91–5.63; I2 = 58; p <.0001, random effects model). The ORs for pharyngeal cancer were 1.35 (95% CI = 0.86–2.12; p = .188, random effects model). Conclusion This study supported the proposition that infection with H. pylori was related to laryngeal carcinoma, specifically in the hospital-based control group and diagnosed by polymerase chain reaction (PCR) or enzyme-linked immunosorbent assay (ELISA). Nevertheless, no significant relationship was discovered between H. pylori infection and pharyngeal cancer. 2015 Wiley Periodicals, Inc. Head Neck, 2015 |
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