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2010-05-22 18:48 |
ysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry
ysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry (Techniques and instrumentation in ytical chemistry) Publisher: Elsevier Science Ltd (September 1984) | IN-10: 0444424180 | 254 pages | PDF | 9.36 MB
PREFACE "Such chemistries reside in the night darkness of the molecule that seems to think , The Striders, Loren Eiseley Loren Eiseley, quoted from "The Striders" in Notes of an Alchemist. Copyright 1972 Loren Eiseley. Used with permission of Charles Scribner's Sons. The brain is one of the most exciting and fertile frontiers of scientific study. A significant amount of time, experimentation, money, and effort is being expended in a multi-faceted scientific research effort to unravel the complexities of the brain. Some of the areas which are being studied include: how the brain receives, processes, and sends information; how pain is dealt with in terms of i t s recognition and i t s reduction; anatomical interconnections among and within brain regions; memory - i t s initial recording, storage, and recall: creative thought; movement disorders; neuroendocrinology : neuropsychiatry; dementia; among many other aspects. Such an area of difficult experimental research necessarily brings into play a wide variety of basic and clinical scientific disciplines, subdisciplines, and experimental techniques which involves biologists, medical personnel, dentists, neurologists, neurochemists, psychiatrists, psychologists, and ytical chemists. Answers sought to questions regarding the brain's functioning require elucidation of the molecular processes that operate within the various brain regions. Only by knowing several aspects of this problem, such as which molecules are involved, their changing concentrations during specific physiological events, their precursors and metabolites, and the enzymatic and regulatory steps which are involved in those transformations, can we treat the human organi in the normal and pathological states in any rational and objective manner. Underpinning all of these research efforts are appropriate ytical tools and techniques which are used to measure the molecules involved with the maximum level of accuracy, precision, sensitivity, and molecular specificity. Accuracy is demanded in these four critical experimental parameters to avoid any confusion or ambiguity in our experiments, conclusions, hypotheses, experiments, protocols, and treatments. Three of the most explosively growing fields in science today include biologically important peptides, high performance liquid chromatography (HPLC), and mass spectrometry (MS). Because of the significant advances in the field of neurobiology , and particular neuropeptides, there now exists an increasingly critical need for dependable structural information. The timing is appropriate to review here the pertinent features of these three areas and to bring into a novel juxtaposition the mutually beneficial aspects of these areas. This book is basically oriented towards a review of the literature, but in those cases where i t is required, more in-depth references will be suggested to the reader. Papers are selected from the wide spectrum of available research, briefly reviewed, and presented here to indicate the panorama of research that is being conducted and to point the way to needed research, An effort has been made to remain up-to-date with respect to the current scientific literature, Because the three fields being discussed represent some of the most rapidly expanding fields in science today, this goal is rather difficult to achieve. Towards resolution of this dilemma, a camera-ready copy is prepared as opposed to a typeset book
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