Practical Process Research & Development
By Neal G. Anderson
354 pages
Publisher: Academic Press; 1st edition (April 15, 2000)
Language: English
-10: 0120594757
IN-13: 978-0120594757
Practical Process Research & Development teaches how to anticipate and avoid problems associated with scale-up from the research lab or pilot plant to full production. The approach is pragmatic, with a minimum of theory and over 100 practical scale-up tips. Many tables and detailed reaction schemes allow the reader to identify critical processing steps quickly.
Target Audience: Novice and experienced process chemists and chemical engineers; especially valuable for anyone entering process chemistry from a classical organic chemistry background; it is also a superb text for students of process chemistry.
Table of Contents:
Approaches to Process Devlopment
Route Selection
Reagent Selection
Solvent Selection
Running the Reaction
Effects of Water
In-Process Controls
Optimizing the Reaction by Minimizing Impurities
Optimizing Catalytic Reactions
Work-up
Tools for Purifying the Product: Column Chromatography, Crystallization, and Reslurrying
Final Product Form and Impurity Considerations
Vessels and Mixing
Preparing for and Implementing the Scale-up Run
Troubleshooting
Chiral Synthesis
Index
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