The role of systemic inflammation linking maternal BMI to neurodevelopment in children
Jelske W. van der Burg ,Sarbattama Sen ,Virginia R. Chomitz ,Jaap C. Seidell ,Alan Leviton,Olaf Dammann,Affiliations
Pediatric Research
doi:10.1038/pr.2015.179
Abstract
Children of obese mothers are at increased risk of developmental adversities. Maternal obesity is linked to an inflammatoryin uteroenvironment, which, in turn, is associated with neurodevelopmental impairments in the offspring. This is an integrated mechani review of animal and human literature related to the hypothesis that maternal obesity causes maternal and fetal inflammation, and that this inflammation adversely affects the neurodevelopment of children. We propose integrative models in which several aspects of inflammation are considered along the causative pathway linking maternal obesity with neurodevelopmental limitations.
