1However, it was not until the 1990s that further clinical and histopathological studies changed the concept and place of NMO within the expanding range of autoimmune disorders of the CNS.
更深入的临床和组织病理学研究才改变了NMO概念和地位,拓展了CNS自身免疫性疾病的范围。
2spatially limited forms such as longitudinally extensive transverse myelitis (LETM) and recurrent isolated optic neuritis (RION)/bilateral optic neuritis (BON) [18,19], (ii) NMO in the context of organ and non-organ-specific autoimmune diseases
(i)空间限定形式,如长节段横贯性脊髓炎(LETM)和复发性单侧视神经炎(RION)/双侧视神经炎(BON)[18,19],(ii) 器官特异性和非器官特异性自身免疫性疾病背景下NMO
3The period for eligible articles ranged from 1965 to September 2009, and following suggestions from the reviewers also individual articles beyond this period
符合条件的文章从1965年至2009年9月,而之后评论文章超出该时期。
4The age of onset in NMO ranges from childhood to late hood with the incidence tapering off after the fifth decade, the median onset age is in the late 30s
NMO发病年龄从儿童期到成年晚期,50岁之后发病率逐渐下降,中位发病年龄在30多岁后期
5 Predictors of a recurrent course were a longer interattack interval between the first two clinical episodes,older age at onset, female gender and less severe motor impairment at the sentinel myelitis event
复发病程预测因素有前两次临床发作间隔时间较长、发病年龄较大、女性和脊髓炎前哨事件中运动损害较轻
6 Acute spinal cord lesions tend to occupy most of the cross-sectional area of an affected segment and are associated with swelling and gadolinium-enhancement (detectable days to months following relapse)
急性脊髓损害占据受累节段横截面的绝大部分,与肿胀和钆增强有关(可见于缓解后数月内)
7 CSF pleocytosis can include or be dominated by neutrophils, also eosinophils may be found
CSF中单个核细胞为或者说占优势的是中性粒细胞,也能发现嗜酸粒细胞
8Patients with LETM are more likely to exhibit a pleocytosis than patients with ON
LETM患者较ON患者脑脊液单个核细胞增多明显